Drug interactions
Clarithromycin + Fedratinib
Severity: Major
Clarithromycin and Fedratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors increase fedratinib exposure, raising the risk of toxicities such as gastrointestinal effects, anemia and encephalopathy including Wernicke's.
What this interaction means in plain words
Clarithromycin and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Fedratinib belongs to Oncology.
Why it happens
Clarithromycin inhibits CYP3A4, a major pathway of fedratinib metabolism.
What to do
Use an alternative antibiotic where possible. If a strong CYP3A4 inhibitor is needed, reduce fedratinib to 200 mg daily as labeled and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Clarithromycin with Fedratinib?
MediHelp rates the interaction as major. Clarithromycin and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase fedratinib exposure, raising the risk of toxicities such as gastrointestinal effects, anemia and encephalopathy including Wernicke's.
How serious is the interaction between Clarithromycin and Fedratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If a strong CYP3A4 inhibitor is needed, reduce fedratinib to 200 mg daily as labeled and monitor for toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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