Drug interactions
Clarithromycin + Fostamatinib
Severity: Moderate
Clarithromycin and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin raises exposure to R406, the active metabolite of fostamatinib, increasing risks of hypertension, diarrhea, hepatotoxicity and neutropenia.
What this interaction means in plain words
Clarithromycin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Fostamatinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces R406 metabolism.
What to do
Monitor blood pressure, liver enzymes and blood counts and reduce the fostamatinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Clarithromycin with Fostamatinib?
MediHelp rates the interaction as moderate. Clarithromycin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin raises exposure to R406, the active metabolite of fostamatinib, increasing risks of hypertension, diarrhea, hepatotoxicity and neutropenia.
How serious is the interaction between Clarithromycin and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, liver enzymes and blood counts and reduce the fostamatinib dose if toxicity occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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