Drug interactions
Clarithromycin + Goserelin
Severity: Moderate
Clarithromycin and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and clarithromycin also prolongs QT. Using both may increase the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Clarithromycin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation: clarithromycin blocks cardiac potassium channels and androgen suppression alters repolarization.
What to do
Check ECG and correct potassium and magnesium before and during the combination in patients with risk factors. Consider azithromycin or another non-macrolide if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Clarithromycin with Goserelin?
MediHelp rates the interaction as moderate. Clarithromycin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and clarithromycin also prolongs QT. Using both may increase the risk of torsades de pointes, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Clarithromycin and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during the combination in patients with risk factors. Consider azithromycin or another non-macrolide if QT risk is high.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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