Drug interactions
Clarithromycin + Indacaterol
Severity: Moderate
Clarithromycin and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and P-glycoprotein and may modestly raise indacaterol exposure, and it also prolongs the QT interval. The combined effect on cardiac repolarization and heart rate may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Clarithromycin and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Indacaterol belongs to Respiratory.
Why it happens
CYP3A4 and P-gp inhibition increasing indacaterol exposure, plus additive QT prolongation.
What to do
Monitor heart rate, ECG and potassium during co-therapy; standard indacaterol doses are generally acceptable, but consider an alternative macrolide in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Indacaterol?
MediHelp rates the interaction as moderate. Clarithromycin and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and P-glycoprotein and may modestly raise indacaterol exposure, and it also prolongs the QT interval. The combined effect on cardiac repolarization and heart rate may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Clarithromycin and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium during co-therapy; standard indacaterol doses are generally acceptable, but consider an alternative macrolide in high-risk patients.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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