Drug interactions
Clarithromycin + Ixazomib
Severity: Minor
Clarithromycin and Ixazomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 inhibitor, but in clinical studies strong CYP3A inhibitors did not meaningfully change ixazomib exposure. No clinically relevant interaction is expected.
What this interaction means in plain words
Clarithromycin and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Ixazomib belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by clarithromycin, which has not translated into meaningful changes in ixazomib exposure.
What to do
No dose adjustment of ixazomib is required; monitor for usual ixazomib adverse effects such as thrombocytopenia and gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Clarithromycin with Ixazomib?
MediHelp rates the interaction as minor. Clarithromycin and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin is a strong CYP3A4 inhibitor, but in clinical studies strong CYP3A inhibitors did not meaningfully change ixazomib exposure. No clinically relevant interaction is expected.
How serious is the interaction between Clarithromycin and Ixazomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of ixazomib is required; monitor for usual ixazomib adverse effects such as thrombocytopenia and gastrointestinal toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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