Drug interactions
Clarithromycin + Lenvatinib
Severity: Moderate
Clarithromycin and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lenvatinib and clarithromycin can prolong the QT interval, so combined use increases the risk of arrhythmia. The risk is greater with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Clarithromycin and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and correct potassium, magnesium and calcium abnormalities. Choose a non-QT-prolonging antibiotic where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Clarithromycin with Lenvatinib?
MediHelp rates the interaction as moderate. Clarithromycin and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both lenvatinib and clarithromycin can prolong the QT interval, so combined use increases the risk of arrhythmia. The risk is greater with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Clarithromycin and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium, magnesium and calcium abnormalities. Choose a non-QT-prolonging antibiotic where practical.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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