Drug interactions
Clarithromycin + Repotrectinib
Severity: Major
Clarithromycin and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may substantially increase repotrectinib exposure, raising the risk of neurologic toxicity such as dizziness and ataxia, as well as hepatotoxicity.
What this interaction means in plain words
Clarithromycin and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Repotrectinib belongs to Oncology.
Why it happens
Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing repotrectinib clearance.
What to do
Avoid concomitant use of strong or moderate CYP3A and P-gp inhibitors and choose an alternative antibiotic. Monitor for neurologic and hepatic adverse effects if exposure cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Clarithromycin with Repotrectinib?
MediHelp rates the interaction as major. Clarithromycin and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may substantially increase repotrectinib exposure, raising the risk of neurologic toxicity such as dizziness and ataxia, as well as hepatotoxicity.
How serious is the interaction between Clarithromycin and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of strong or moderate CYP3A and P-gp inhibitors and choose an alternative antibiotic. Monitor for neurologic and hepatic adverse effects if exposure cannot be avoided.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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