Drug interactions
Clarithromycin + Rucaparib
Severity: Minor
Clarithromycin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate inhibitor of CYP3A4, so it may modestly increase clarithromycin exposure. The effect is generally modest, but clarithromycin has dose-related toxicity such as QT prolongation.
What this interaction means in plain words
Clarithromycin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing clarithromycin metabolism.
What to do
No routine dose change is needed. Monitor for clarithromycin adverse effects such as GI upset or palpitations, particularly in patients with renal impairment or other risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Clarithromycin with Rucaparib?
MediHelp rates the interaction as minor. Clarithromycin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate inhibitor of CYP3A4, so it may modestly increase clarithromycin exposure. The effect is generally modest, but clarithromycin has dose-related toxicity such as QT prolongation.
How serious is the interaction between Clarithromycin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for clarithromycin adverse effects such as GI upset or palpitations, particularly in patients with renal impairment or other risk factors.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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