Drug interactions
Clarithromycin + Ruxolitinib
Severity: Moderate
Clarithromycin and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin increases ruxolitinib exposure, which may worsen cytopenias such as thrombocytopenia and neutropenia. Dose adjustment is recommended with strong CYP3A4 inhibitors.
What this interaction means in plain words
Clarithromycin and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Ruxolitinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces ruxolitinib clearance.
What to do
Reduce the ruxolitinib dose according to labeling and platelet count, and monitor blood counts frequently. Consider azithromycin as an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Clarithromycin with Ruxolitinib?
MediHelp rates the interaction as moderate. Clarithromycin and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin increases ruxolitinib exposure, which may worsen cytopenias such as thrombocytopenia and neutropenia. Dose adjustment is recommended with strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose according to labeling and platelet count, and monitor blood counts frequently. Consider azithromycin as an alternative antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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