Drug interactions
Clarithromycin + Stiripentol
Severity: Moderate
Clarithromycin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase stiripentol exposure, potentially causing sedation, ataxia and other dose-related adverse effects. Stiripentol is itself a CYP inhibitor and is often combined with other antiseizure drugs.
What this interaction means in plain words
Clarithromycin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Stiripentol belongs to Central Nervous System.
Why it happens
Clarithromycin inhibits CYP3A4, which contributes to stiripentol metabolism.
What to do
Monitor for sedation, ataxia and gastrointestinal effects during clarithromycin therapy. Consider an alternative antibiotic or reduce the stiripentol dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Clarithromycin with Stiripentol?
MediHelp rates the interaction as moderate. Clarithromycin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase stiripentol exposure, potentially causing sedation, ataxia and other dose-related adverse effects. Stiripentol is itself a CYP inhibitor and is often combined with other antiseizure drugs.
How serious is the interaction between Clarithromycin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and gastrointestinal effects during clarithromycin therapy. Consider an alternative antibiotic or reduce the stiripentol dose if toxicity occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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