Drug interactions
Clarithromycin + Temsirolimus
Severity: Major
Clarithromycin and Temsirolimus: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of adverse effects such as mucositis, cytopenias and metabolic disturbances.
What this interaction means in plain words
Clarithromycin and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Temsirolimus belongs to Oncology.
Why it happens
CYP3A4 inhibition reduces metabolism of temsirolimus and its metabolite sirolimus.
What to do
Choose a non-CYP3A4-inhibiting antibiotic. If unavoidable, consider a temsirolimus dose reduction per labeling and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Clarithromycin with Temsirolimus?
MediHelp rates the interaction as major. Clarithromycin and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of adverse effects such as mucositis, cytopenias and metabolic disturbances.
How serious is the interaction between Clarithromycin and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-CYP3A4-inhibiting antibiotic. If unavoidable, consider a temsirolimus dose reduction per labeling and monitor for toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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