Drug interactions
Clevidipine + Melatonin
Severity: Minor
Clevidipine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported to raise blood pressure in some patients taking dihydropyridine calcium channel blockers, which could reduce their antihypertensive effect. Evidence is limited, and clevidipine is titrated to effect in monitored settings.
What this interaction means in plain words
Clevidipine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clevidipine belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Possible pharmacodynamic antagonism of vasodilation; the mechanism is not well established.
What to do
Titrate clevidipine to the target blood pressure with routine monitoring; no other action is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Melatonin?
MediHelp rates the interaction as minor. Clevidipine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has been reported to raise blood pressure in some patients taking dihydropyridine calcium channel blockers, which could reduce their antihypertensive effect. Evidence is limited, and clevidipine is titrated to effect in monitored settings.
How serious is the interaction between Clevidipine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to the target blood pressure with routine monitoring; no other action is required.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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