Drug interactions
Clevidipine + Sotalol
Severity: Moderate
Clevidipine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine lowers blood pressure by arterial vasodilation, and sotalol adds beta-blockade, so hypotension and bradycardia may be greater. Reflex tachycardia from clevidipine may be blunted by sotalol.
What this interaction means in plain words
Clevidipine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from dihydropyridine calcium channel blockade and beta-blockade.
What to do
Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring, and reduce the infusion rate if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clevidipine and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Sotalol?
MediHelp rates the interaction as moderate. Clevidipine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine lowers blood pressure by arterial vasodilation, and sotalol adds beta-blockade, so hypotension and bradycardia may be greater. Reflex tachycardia from clevidipine may be blunted by sotalol.
How serious is the interaction between Clevidipine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring, and reduce the infusion rate if hypotension occurs.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
