Drug interactions
Clevidipine + Temsirolimus
Severity: Minor
Clevidipine and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors are associated with angioedema, and the risk appears higher with some other agents that affect vascular or bradykinin pathways. Evidence for calcium channel blockers with temsirolimus is limited.
What this interaction means in plain words
Clevidipine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clevidipine belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Possible additive predisposition to angioedema; mechanism not well established.
What to do
Be aware of the risk and counsel patients to report facial, lip or tongue swelling promptly. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Temsirolimus?
MediHelp rates the interaction as minor. Clevidipine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. mTOR inhibitors are associated with angioedema, and the risk appears higher with some other agents that affect vascular or bradykinin pathways. Evidence for calcium channel blockers with temsirolimus is limited.
How serious is the interaction between Clevidipine and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the risk and counsel patients to report facial, lip or tongue swelling promptly. No routine dose change is required.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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