Drug interactions
Clobazam + Dantrolene
Severity: Moderate
Clobazam and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that causes sedation and may depress respiration, and dantrolene adds drowsiness. Combined use can increase CNS depression and impair psychomotor performance.
What this interaction means in plain words
Clobazam and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor sedation and respiratory function, especially at initiation or dose increases. Counsel about driving and avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clobazam and Dantrolene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dantrolene
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Dantrolene?
MediHelp rates the interaction as moderate. Clobazam and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that causes sedation and may depress respiration, and dantrolene adds drowsiness. Combined use can increase CNS depression and impair psychomotor performance.
How serious is the interaction between Clobazam and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, especially at initiation or dose increases. Counsel about driving and avoiding alcohol.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
