Drug interactions
Clobazam + Duloxetine
Severity: Minor
Clobazam and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP2D6 inhibitor, and duloxetine is metabolized by CYP1A2 and CYP2D6. Duloxetine exposure may rise slightly, but the effect is likely small. Additive sedation between the two drugs is also possible.
What this interaction means in plain words
Clobazam and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam may modestly reduce duloxetine clearance, with additive CNS effects.
What to do
No routine dose change is needed. Monitor for duloxetine adverse effects and excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Duloxetine?
MediHelp rates the interaction as minor. Clobazam and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam is a weak CYP2D6 inhibitor, and duloxetine is metabolized by CYP1A2 and CYP2D6. Duloxetine exposure may rise slightly, but the effect is likely small. Additive sedation between the two drugs is also possible.
How serious is the interaction between Clobazam and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for duloxetine adverse effects and excess sedation.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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