Drug interactions
Clobazam + Esomeprazole
Severity: Moderate
Clobazam and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole may increase exposure to N-desmethylclobazam, the active metabolite of clobazam. This can increase sedation, drowsiness and other CNS effects.
What this interaction means in plain words
Clobazam and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2C19 slows conversion and clearance of N-desmethylclobazam.
What to do
Monitor for sedation and adjust the clobazam dose downward if adverse effects occur, especially in CYP2C19 poor metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Esomeprazole?
MediHelp rates the interaction as moderate. Clobazam and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esomeprazole may increase exposure to N-desmethylclobazam, the active metabolite of clobazam. This can increase sedation, drowsiness and other CNS effects.
How serious is the interaction between Clobazam and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and adjust the clobazam dose downward if adverse effects occur, especially in CYP2C19 poor metabolizers.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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