Drug interactions
Clobazam + Fenfluramine
Severity: Minor
Clobazam and Fenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam does not clearly affect fenfluramine on its own, and the labeled increase in fenfluramine exposure relates to the stiripentol and clobazam regimen as a whole, which is attributable to stiripentol. Both drugs cause sedation, so additive somnolence may occur.
What this interaction means in plain words
Clobazam and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive CNS depression; no significant pharmacokinetic effect of clobazam alone is established.
What to do
Monitor for sedation when the two are used together. Adjust the dose if somnolence becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Fenfluramine?
MediHelp rates the interaction as minor. Clobazam and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam does not clearly affect fenfluramine on its own, and the labeled increase in fenfluramine exposure relates to the stiripentol and clobazam regimen as a whole, which is attributable to stiripentol. Both drugs cause sedation, so additive somnolence may occur.
How serious is the interaction between Clobazam and Fenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation when the two are used together. Adjust the dose if somnolence becomes troublesome.
What other medicines interact with Fenfluramine?
MediHelp also lists interactions of Fenfluramine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Fenfluramine page.
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