Drug interactions
Clobazam + Fluconazole
Severity: Moderate
Clobazam and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19, which forms the less active and clears the active metabolite N-desmethylclobazam, so exposure to the active metabolite increases. This may cause greater sedation, drowsiness, ataxia and cognitive impairment.
What this interaction means in plain words
Clobazam and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C19-mediated clearance of N-desmethylclobazam by fluconazole.
What to do
Monitor for sedation and reduced alertness and consider lowering the clobazam dose. Adjust again when fluconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Fluconazole?
MediHelp rates the interaction as moderate. Clobazam and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C19, which forms the less active and clears the active metabolite N-desmethylclobazam, so exposure to the active metabolite increases. This may cause greater sedation, drowsiness, ataxia and cognitive impairment.
How serious is the interaction between Clobazam and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduced alertness and consider lowering the clobazam dose. Adjust again when fluconazole is stopped.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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