Drug interactions
Clobazam + Methamphetamine
Severity: Minor
Clobazam and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP2D6 inhibitor and methamphetamine is partly metabolized by CYP2D6. Exposure to methamphetamine may rise modestly, increasing stimulant and cardiovascular effects. The effect is generally small.
What this interaction means in plain words
Clobazam and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6 by clobazam reduces methamphetamine metabolism.
What to do
Monitor for increased stimulant effects such as tachycardia and hypertension. Reduce the methamphetamine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Methamphetamine?
MediHelp rates the interaction as minor. Clobazam and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam is a weak CYP2D6 inhibitor and methamphetamine is partly metabolized by CYP2D6. Exposure to methamphetamine may rise modestly, increasing stimulant and cardiovascular effects. The effect is generally small.
How serious is the interaction between Clobazam and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects such as tachycardia and hypertension. Reduce the methamphetamine dose if these occur.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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