Drug interactions
Clobazam + Mirtazapine
Severity: Moderate
Clobazam and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and together they may increase drowsiness, dizziness and impaired psychomotor performance. Clobazam is a weak CYP2D6 inhibitor, which could modestly raise mirtazapine concentrations.
What this interaction means in plain words
Clobazam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and H1 antagonism, with weak CYP2D6 inhibition by clobazam.
What to do
Monitor for oversedation and reduce the mirtazapine dose if needed. Advise avoiding alcohol and driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Mirtazapine?
MediHelp rates the interaction as moderate. Clobazam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and together they may increase drowsiness, dizziness and impaired psychomotor performance. Clobazam is a weak CYP2D6 inhibitor, which could modestly raise mirtazapine concentrations.
How serious is the interaction between Clobazam and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the mirtazapine dose if needed. Advise avoiding alcohol and driving until tolerance is established.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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