Drug interactions
Clobazam + Modafinil
Severity: Moderate
Clobazam and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil can inhibit CYP2C19, which converts the active metabolite N-desmethylclobazam to inactive products, so metabolite exposure may rise. This may increase sedation, dizziness and psychomotor impairment. Modafinil may also weakly induce CYP3A4, which could affect clobazam formation of its metabolite.
What this interaction means in plain words
Clobazam and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by modafinil reduces clearance of N-desmethylclobazam.
What to do
Monitor for excess sedation and adverse effects and consider reducing the clobazam dose. Reassess seizure control after any change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Modafinil?
MediHelp rates the interaction as moderate. Clobazam and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil can inhibit CYP2C19, which converts the active metabolite N-desmethylclobazam to inactive products, so metabolite exposure may rise. This may increase sedation, dizziness and psychomotor impairment. Modafinil may also weakly induce CYP3A4, which could affect clobazam formation of its metabolite.
How serious is the interaction between Clobazam and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and adverse effects and consider reducing the clobazam dose. Reassess seizure control after any change.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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