Drug interactions
Clobazam + Risperidone
Severity: Moderate
Clobazam and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so concurrent use can intensify sedation and, less commonly, respiratory depression. Clobazam is a weak CYP2D6 inhibitor and may slightly increase risperidone exposure.
What this interaction means in plain words
Clobazam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus weak CYP2D6 inhibition by clobazam.
What to do
Monitor for sedation and respiratory depression, particularly at initiation or dose increases. Lower the risperidone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Risperidone?
MediHelp rates the interaction as moderate. Clobazam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so concurrent use can intensify sedation and, less commonly, respiratory depression. Clobazam is a weak CYP2D6 inhibitor and may slightly increase risperidone exposure.
How serious is the interaction between Clobazam and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, particularly at initiation or dose increases. Lower the risperidone dose if adverse effects appear.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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