Drug interactions
Clobazam + Stiripentol
Severity: Moderate
Clobazam and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol raises clobazam and norclobazam concentrations, causing greater sedation, somnolence and hypotonia. The effect is well recognised in Dravet syndrome treatment.
What this interaction means in plain words
Clobazam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 and CYP3A4 by stiripentol reduces clearance of clobazam and its active metabolite.
What to do
Monitor for sedation and reduce the clobazam dose if adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Stiripentol
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Stiripentol?
MediHelp rates the interaction as moderate. Clobazam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol raises clobazam and norclobazam concentrations, causing greater sedation, somnolence and hypotonia. The effect is well recognised in Dravet syndrome treatment.
How serious is the interaction between Clobazam and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduce the clobazam dose if adverse reactions occur.
What other medicines interact with Stiripentol?
MediHelp also lists interactions of Stiripentol with, for example, Apalutamide, Clomipramine, Ergotamine. The full list is on the Stiripentol page.
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