Drug interactions
Clobazam + Vigabatrin
Severity: Moderate
Clobazam and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that produces sedation and can depress respiration, and vigabatrin also causes somnolence and fatigue. The combination is common in refractory epilepsy and may increase drowsiness and cognitive slowing.
What this interaction means in plain words
Clobazam and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABAergic mechanisms (GABA-A potentiation by clobazam and GABA transaminase inhibition by vigabatrin).
What to do
Monitor for sedation and, in vulnerable patients, respiratory depression, and adjust doses by clinical response. Introduce changes gradually and counsel on impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Vigabatrin?
MediHelp rates the interaction as moderate. Clobazam and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that produces sedation and can depress respiration, and vigabatrin also causes somnolence and fatigue. The combination is common in refractory epilepsy and may increase drowsiness and cognitive slowing.
How serious is the interaction between Clobazam and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and, in vulnerable patients, respiratory depression, and adjust doses by clinical response. Introduce changes gradually and counsel on impaired alertness.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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