Drug interactions
Clofazimine + Ozanimod
Severity: Moderate
Clofazimine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod may slow heart rate at initiation, while clofazimine prolongs the QT interval. Bradycardia plus QT prolongation can increase the risk of torsades de pointes.
What this interaction means in plain words
Clofazimine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects of ozanimod-related bradycardia and clofazimine-related QT prolongation.
What to do
Obtain an ECG before starting ozanimod and seek cardiology advice before initiating in patients taking clofazimine. Monitor heart rate and QTc afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Clofazimine with Ozanimod?
MediHelp rates the interaction as moderate. Clofazimine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod may slow heart rate at initiation, while clofazimine prolongs the QT interval. Bradycardia plus QT prolongation can increase the risk of torsades de pointes.
How serious is the interaction between Clofazimine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology advice before initiating in patients taking clofazimine. Monitor heart rate and QTc afterwards.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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