Drug interactions
Clofazimine + Triclabendazole
Severity: Moderate
Clofazimine and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole has been associated with QT prolongation and clofazimine may also lengthen the QT interval. Combined use could increase the risk of ventricular arrhythmias, mainly in patients with other risk factors.
What this interaction means in plain words
Clofazimine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolyte disturbances before starting. Repeat the ECG if the patient has symptoms or additional risk factors, and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Triclabendazole
Frequently asked questions
Can I take Clofazimine with Triclabendazole?
MediHelp rates the interaction as moderate. Clofazimine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole has been associated with QT prolongation and clofazimine may also lengthen the QT interval. Combined use could increase the risk of ventricular arrhythmias, mainly in patients with other risk factors.
How serious is the interaction between Clofazimine and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte disturbances before starting. Repeat the ECG if the patient has symptoms or additional risk factors, and avoid further QT-prolonging drugs.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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