Drug interactions
Clomipramine + Dantrolene
Severity: Moderate
Clomipramine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is sedating and anticholinergic, and with dantrolene it can cause significant drowsiness and impaired coordination. Older patients are at greater risk of falls and confusion.
What this interaction means in plain words
Clomipramine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression from tricyclic antihistaminic and anticholinergic effects plus dantrolene's central effects.
What to do
Use the lowest effective doses and counsel on sedation and driving. Reduce doses if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Dantrolene?
MediHelp rates the interaction as moderate. Clomipramine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is sedating and anticholinergic, and with dantrolene it can cause significant drowsiness and impaired coordination. Older patients are at greater risk of falls and confusion.
How serious is the interaction between Clomipramine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on sedation and driving. Reduce doses if drowsiness is excessive.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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