Drug interactions
Clomipramine + Dihydroergotamine
Severity: Moderate
Clomipramine and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity and the combination may increase the risk of serotonin syndrome. Clomipramine, a CYP2D6/3A4 substrate, may also add to vasoconstrictive or cardiovascular effects in susceptible patients.
What this interaction means in plain words
Clomipramine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from serotonin reuptake inhibition and serotonin receptor agonism.
What to do
Monitor for agitation, tremor, hyperthermia and autonomic instability after dihydroergotamine dosing. Counsel the patient on symptoms and stop treatment if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Clomipramine with Dihydroergotamine?
MediHelp rates the interaction as moderate. Clomipramine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity and the combination may increase the risk of serotonin syndrome. Clomipramine, a CYP2D6/3A4 substrate, may also add to vasoconstrictive or cardiovascular effects in susceptible patients.
How serious is the interaction between Clomipramine and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and autonomic instability after dihydroergotamine dosing. Counsel the patient on symptoms and stop treatment if serotonin syndrome is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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