Drug interactions
Clomipramine + Ergotamine
Severity: Moderate
Clomipramine and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine may add serotonergic effects to ergotamine, and ergotamine's vasoconstrictor action may be potentiated, raising the risk of serotonin syndrome and ischemia. The evidence is limited, but ergot toxicity is serious.
What this interaction means in plain words
Clomipramine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity, with possible enhancement of ergot vasoconstriction.
What to do
Avoid combining where alternatives exist, and monitor for serotonin toxicity and for peripheral ischemia such as cold, painful or numb extremities. Stop ergotamine if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Clomipramine with Ergotamine?
MediHelp rates the interaction as moderate. Clomipramine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine may add serotonergic effects to ergotamine, and ergotamine's vasoconstrictor action may be potentiated, raising the risk of serotonin syndrome and ischemia. The evidence is limited, but ergot toxicity is serious.
How serious is the interaction between Clomipramine and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where alternatives exist, and monitor for serotonin toxicity and for peripheral ischemia such as cold, painful or numb extremities. Stop ergotamine if these occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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