Drug interactions
Clomipramine + Estradiol
Severity: Moderate
Clomipramine and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant concentrations, leading to more anticholinergic, sedative and cardiovascular effects. Conversely, some reports suggest reduced antidepressant effect, so the direction of change is unpredictable.
What this interaction means in plain words
Clomipramine and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Estradiol belongs to Endocrine.
Why it happens
Possible inhibition of tricyclic hepatic metabolism by estrogens; the mechanism is not firmly established.
What to do
Monitor for tricyclic adverse effects and changes in antidepressant response when estrogen is started, stopped or changed. Adjust the clomipramine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Clomipramine with Estradiol?
MediHelp rates the interaction as moderate. Clomipramine and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens may raise tricyclic antidepressant concentrations, leading to more anticholinergic, sedative and cardiovascular effects. Conversely, some reports suggest reduced antidepressant effect, so the direction of change is unpredictable.
How serious is the interaction between Clomipramine and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and changes in antidepressant response when estrogen is started, stopped or changed. Adjust the clomipramine dose accordingly.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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