Drug interactions
Clomipramine + Fedratinib
Severity: Moderate
Clomipramine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6 and CYP2C19, and these enzymes contribute to the clearance of clomipramine and its active metabolite desmethylclomipramine. Exposure to clomipramine may rise, increasing anticholinergic effects, sedation, cardiac conduction effects and seizure risk.
What this interaction means in plain words
Clomipramine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP2D6 and CYP2C19, reducing the metabolism of clomipramine.
What to do
Monitor for tricyclic adverse effects and consider reducing the clomipramine dose, guided by clinical response and plasma levels or ECG where available. Reassess if fedratinib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Clomipramine with Fedratinib?
MediHelp rates the interaction as moderate. Clomipramine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6 and CYP2C19, and these enzymes contribute to the clearance of clomipramine and its active metabolite desmethylclomipramine. Exposure to clomipramine may rise, increasing anticholinergic effects, sedation, cardiac conduction effects and seizure risk.
How serious is the interaction between Clomipramine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider reducing the clomipramine dose, guided by clinical response and plasma levels or ECG where available. Reassess if fedratinib is started or stopped.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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