Drug interactions
Clomipramine + Fenfluramine
Severity: Major
Clomipramine and Fenfluramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine releases serotonin and clomipramine blocks its reuptake, so together they can precipitate serotonin syndrome. Clomipramine is also a CYP2D6 substrate, and fenfluramine's metabolism involves several CYP enzymes.
What this interaction means in plain words
Clomipramine and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity through serotonin release and reuptake inhibition.
What to do
Avoid if possible; otherwise monitor for serotonin syndrome signs such as agitation, tremor, clonus and hyperthermia. Stop one agent if symptoms appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Fenfluramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Clomipramine with Fenfluramine?
MediHelp rates the interaction as major. Clomipramine and Fenfluramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenfluramine releases serotonin and clomipramine blocks its reuptake, so together they can precipitate serotonin syndrome. Clomipramine is also a CYP2D6 substrate, and fenfluramine's metabolism involves several CYP enzymes.
How serious is the interaction between Clomipramine and Fenfluramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for serotonin syndrome signs such as agitation, tremor, clonus and hyperthermia. Stop one agent if symptoms appear.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
