Drug interactions
Clomipramine + Melatonin
Severity: Minor
Clomipramine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative effects that may add to the drowsiness caused by clomipramine. The clinical effect is usually modest and often used intentionally for sleep.
What this interaction means in plain words
Clomipramine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS sedation; some tricyclics may also modestly increase melatonin levels.
What to do
Take melatonin at bedtime and advise caution with driving if morning drowsiness occurs. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Clomipramine with Melatonin?
MediHelp rates the interaction as minor. Clomipramine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative effects that may add to the drowsiness caused by clomipramine. The clinical effect is usually modest and often used intentionally for sleep.
How serious is the interaction between Clomipramine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take melatonin at bedtime and advise caution with driving if morning drowsiness occurs. No dose change is usually required.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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