Drug interactions
Clomipramine + Methamphetamine
Severity: Major
Clomipramine and Methamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can increase and prolong the effects of amphetamines, with risk of hypertension, tachycardia, arrhythmia and agitation. Serotonin toxicity and seizures are also possible.
What this interaction means in plain words
Clomipramine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Clomipramine blocks norepinephrine reuptake and inhibits CYP2D6 metabolism of methamphetamine, adding to monoamine release.
What to do
Avoid if possible; if used together, monitor blood pressure, heart rate, ECG and mental status, and use lower doses of the stimulant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Clomipramine with Methamphetamine?
MediHelp rates the interaction as major. Clomipramine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics can increase and prolong the effects of amphetamines, with risk of hypertension, tachycardia, arrhythmia and agitation. Serotonin toxicity and seizures are also possible.
How serious is the interaction between Clomipramine and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used together, monitor blood pressure, heart rate, ECG and mental status, and use lower doses of the stimulant.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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