Drug interactions
Clomipramine + Modafinil
Severity: Moderate
Clomipramine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and may offset sedation from clomipramine. Modafinil may also inhibit CYP2C19 and raise clomipramine levels, as seen with some tricyclics, increasing tricyclic adverse effects.
What this interaction means in plain words
Clomipramine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Possible CYP2C19 inhibition by modafinil reducing clomipramine metabolism; opposing effects on alertness.
What to do
Monitor for tricyclic adverse effects such as anticholinergic symptoms and cardiac effects, and consider dose reduction of clomipramine if they occur. Review blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Clomipramine with Modafinil?
MediHelp rates the interaction as moderate. Clomipramine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil promotes wakefulness and may offset sedation from clomipramine. Modafinil may also inhibit CYP2C19 and raise clomipramine levels, as seen with some tricyclics, increasing tricyclic adverse effects.
How serious is the interaction between Clomipramine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as anticholinergic symptoms and cardiac effects, and consider dose reduction of clomipramine if they occur. Review blood pressure and heart rate.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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