Drug interactions
Clomipramine + Oxycodone
Severity: Moderate
Clomipramine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine adds sedation and anticholinergic effects to oxycodone, and it also has serotonergic activity so serotonin syndrome is possible with opioids. Clomipramine is a CYP2D6 substrate and its effects may be additive with opioid CNS depression.
What this interaction means in plain words
Clomipramine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with a possible additive serotonergic effect.
What to do
Monitor for excessive sedation and for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus; lower doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Oxycodone?
MediHelp rates the interaction as moderate. Clomipramine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine adds sedation and anticholinergic effects to oxycodone, and it also has serotonergic activity so serotonin syndrome is possible with opioids. Clomipramine is a CYP2D6 substrate and its effects may be additive with opioid CNS depression.
How serious is the interaction between Clomipramine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus; lower doses if needed.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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