Drug interactions
Clomipramine + Pregabalin
Severity: Moderate
Clomipramine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, and together they can increase central nervous system depression, impaired psychomotor performance and falls. Respiratory depression is a concern mainly in older patients, those with lung disease or when other depressants are co-prescribed.
What this interaction means in plain words
Clomipramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through different pharmacodynamic mechanisms.
What to do
Start with low doses and titrate slowly, monitoring for sedation, confusion and respiratory depression. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Clomipramine with Pregabalin?
MediHelp rates the interaction as moderate. Clomipramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, and together they can increase central nervous system depression, impaired psychomotor performance and falls. Respiratory depression is a concern mainly in older patients, those with lung disease or when other depressants are co-prescribed.
How serious is the interaction between Clomipramine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, monitoring for sedation, confusion and respiratory depression. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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