Drug interactions
Clomipramine + Propylhexedrine
Severity: Moderate
Clomipramine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an indirectly acting sympathomimetic decongestant, and clomipramine can change the pressor and cardiac response to it. The effect may be exaggerated or blunted, and hypertension or tachyarrhythmia can occur. Systemic exposure from inhaled use is usually small, which limits the risk.
What this interaction means in plain words
Clomipramine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Clomipramine blocks norepinephrine reuptake and the neuronal uptake of indirect sympathomimetics, altering the adrenergic response.
What to do
Avoid repeated or excessive use of propylhexedrine in patients on clomipramine. Monitor blood pressure and heart rate if use is necessary, and consider a non-sympathomimetic decongestant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Clomipramine with Propylhexedrine?
MediHelp rates the interaction as moderate. Clomipramine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is an indirectly acting sympathomimetic decongestant, and clomipramine can change the pressor and cardiac response to it. The effect may be exaggerated or blunted, and hypertension or tachyarrhythmia can occur. Systemic exposure from inhaled use is usually small, which limits the risk.
How serious is the interaction between Clomipramine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeated or excessive use of propylhexedrine in patients on clomipramine. Monitor blood pressure and heart rate if use is necessary, and consider a non-sympathomimetic decongestant.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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