Drug interactions
Clomipramine + Risperidone
Severity: Moderate
Clomipramine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval and cause sedation, so arrhythmia risk and drowsiness may increase. Clomipramine may also raise risperidone exposure through CYP2D6 inhibition.
What this interaction means in plain words
Clomipramine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression, plus possible CYP2D6 inhibition by clomipramine raising risperidone levels.
What to do
Check a baseline ECG and electrolytes and monitor ECG after dose changes. Watch for extrapyramidal symptoms, hypotension and sedation, and reduce the risperidone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Clomipramine with Risperidone?
MediHelp rates the interaction as moderate. Clomipramine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval and cause sedation, so arrhythmia risk and drowsiness may increase. Clomipramine may also raise risperidone exposure through CYP2D6 inhibition.
How serious is the interaction between Clomipramine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor ECG after dose changes. Watch for extrapyramidal symptoms, hypotension and sedation, and reduce the risperidone dose if they occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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