Drug interactions
Clomipramine + Rizatriptan
Severity: Moderate
Clomipramine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine strongly inhibits serotonin reuptake and rizatriptan stimulates serotonin receptors, so combined use could theoretically precipitate serotonin syndrome. Documented cases with tricyclics are uncommon but the reaction can be serious.
What this interaction means in plain words
Clomipramine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from serotonin reuptake inhibition plus 5-HT1B/1D agonism.
What to do
Counsel the patient to report agitation, tremor, sweating, diarrhea or fever after dosing. Stop the triptan and treat if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Clomipramine with Rizatriptan?
MediHelp rates the interaction as moderate. Clomipramine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine strongly inhibits serotonin reuptake and rizatriptan stimulates serotonin receptors, so combined use could theoretically precipitate serotonin syndrome. Documented cases with tricyclics are uncommon but the reaction can be serious.
How serious is the interaction between Clomipramine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, diarrhea or fever after dosing. Stop the triptan and treat if serotonin toxicity is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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