Drug interactions
Clomipramine + Sevoflurane
Severity: Moderate
Clomipramine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can sensitize the myocardium to arrhythmias during volatile anesthesia, and both drugs may prolong the QT interval. Hypotension and enhanced CNS depression may also occur.
What this interaction means in plain words
Clomipramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, CNS depression and cardiovascular effects of the tricyclic and the volatile anesthetic.
What to do
Inform the anesthesia team of tricyclic use and monitor ECG and blood pressure continuously during anesthesia. Avoid other QT-prolonging drugs perioperatively and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Clomipramine with Sevoflurane?
MediHelp rates the interaction as moderate. Clomipramine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can sensitize the myocardium to arrhythmias during volatile anesthesia, and both drugs may prolong the QT interval. Hypotension and enhanced CNS depression may also occur.
How serious is the interaction between Clomipramine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of tricyclic use and monitor ECG and blood pressure continuously during anesthesia. Avoid other QT-prolonging drugs perioperatively and correct electrolytes.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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