Drug interactions
Clomipramine + Tiotropium-olodaterol
Severity: Moderate
Clomipramine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has strong anticholinergic effects that add to those of tiotropium, causing dry mouth, constipation, urinary retention and possibly raised intraocular pressure. It also prolongs the QT interval and can potentiate the cardiovascular effects of beta2 agonists, including arrhythmias.
What this interaction means in plain words
Clomipramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive cardiac effects (QT prolongation, adrenergic stimulation).
What to do
Monitor for anticholinergic adverse effects and obtain an ECG in patients with cardiac disease. Correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Clomipramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has strong anticholinergic effects that add to those of tiotropium, causing dry mouth, constipation, urinary retention and possibly raised intraocular pressure. It also prolongs the QT interval and can potentiate the cardiovascular effects of beta2 agonists, including arrhythmias.
How serious is the interaction between Clomipramine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and obtain an ECG in patients with cardiac disease. Correct electrolyte disturbances.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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