Drug interactions
Clomipramine + Triclabendazole
Severity: Minor
Clomipramine and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole may inhibit CYP2C19, which participates in clomipramine metabolism, so clomipramine levels might increase. The effect is expected to be modest and temporary given the short treatment course.
What this interaction means in plain words
Clomipramine and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19 reduces clomipramine metabolism.
What to do
Monitor for anticholinergic, sedative and cardiac adverse effects during and shortly after triclabendazole. Reduce the clomipramine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Clomipramine with Triclabendazole?
MediHelp rates the interaction as minor. Clomipramine and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole may inhibit CYP2C19, which participates in clomipramine metabolism, so clomipramine levels might increase. The effect is expected to be modest and temporary given the short treatment course.
How serious is the interaction between Clomipramine and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic, sedative and cardiac adverse effects during and shortly after triclabendazole. Reduce the clomipramine dose if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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