Drug interactions
Clomipramine + Valbenazine
Severity: Moderate
Clomipramine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures and clomipramine has similar effects, so the combination may increase the risk of arrhythmia. Clomipramine inhibits CYP2D6, which may increase exposure to active valbenazine metabolite.
What this interaction means in plain words
Clomipramine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with possible CYP2D6-mediated increase in valbenazine exposure.
What to do
Obtain a baseline ECG and keep potassium and magnesium within normal range. Monitor for palpitations, syncope and excessive sedation, and avoid use in patients with long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Clomipramine with Valbenazine?
MediHelp rates the interaction as moderate. Clomipramine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures and clomipramine has similar effects, so the combination may increase the risk of arrhythmia. Clomipramine inhibits CYP2D6, which may increase exposure to active valbenazine metabolite.
How serious is the interaction between Clomipramine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and keep potassium and magnesium within normal range. Monitor for palpitations, syncope and excessive sedation, and avoid use in patients with long QT.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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