Drug interactions
Clomipramine + Zileuton
Severity: Moderate
Clomipramine and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton inhibits CYP1A2, which participates in clomipramine demethylation, so clomipramine levels may rise. This may increase anticholinergic effects, sedation, seizure risk and cardiac toxicity.
What this interaction means in plain words
Clomipramine and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Inhibition of CYP1A2-mediated clomipramine metabolism by zileuton.
What to do
Monitor for tricyclic adverse effects and consider reducing the clomipramine dose. Check plasma levels or ECG if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Zileuton?
MediHelp rates the interaction as moderate. Clomipramine and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton inhibits CYP1A2, which participates in clomipramine demethylation, so clomipramine levels may rise. This may increase anticholinergic effects, sedation, seizure risk and cardiac toxicity.
How serious is the interaction between Clomipramine and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider reducing the clomipramine dose. Check plasma levels or ECG if toxicity is suspected.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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