Drug interactions
Clopidogrel + Posaconazole
Severity: Moderate
Clopidogrel and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel is a prodrug that needs CYP-mediated activation, partly via CYP3A4, to form its active thiol metabolite. Posaconazole, a strong CYP3A4 inhibitor, may lower active metabolite formation and weaken platelet inhibition. The clinical significance is uncertain, but reduced antiplatelet effect could matter in stented or high-risk patients.
What this interaction means in plain words
Clopidogrel and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, which contributes to the bioactivation of clopidogrel, so less active metabolite is produced.
What to do
In patients at high thrombotic risk, consider an alternative antifungal or an alternative antiplatelet agent not dependent on CYP activation. Otherwise watch for signs of thrombotic events and consider platelet function testing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Posaconazole?
MediHelp rates the interaction as moderate. Clopidogrel and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel is a prodrug that needs CYP-mediated activation, partly via CYP3A4, to form its active thiol metabolite. Posaconazole, a strong CYP3A4 inhibitor, may lower active metabolite formation and weaken platelet inhibition. The clinical significance is uncertain, but reduced antiplatelet effect could matter in stented or high-risk patients.
How serious is the interaction between Clopidogrel and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients at high thrombotic risk, consider an alternative antifungal or an alternative antiplatelet agent not dependent on CYP activation. Otherwise watch for signs of thrombotic events and consider platelet function testing.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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