Drug interactions
Clopidogrel + Sodium zirconium cyclosilicate
Severity: Minor
Clopidogrel and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can transiently raise gastric pH, which may alter absorption of drugs whose bioavailability depends on gastric acidity. Clopidogrel is not strongly pH dependent, so the effect is likely small.
What this interaction means in plain words
Clopidogrel and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Possible reduced absorption of clopidogrel due to increased gastric pH; the mechanism is not well established.
What to do
Separate administration by at least 2 hours as labeling recommends for pH-sensitive drugs. No further action is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Clopidogrel with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Clopidogrel and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate can transiently raise gastric pH, which may alter absorption of drugs whose bioavailability depends on gastric acidity. Clopidogrel is not strongly pH dependent, so the effect is likely small.
How serious is the interaction between Clopidogrel and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours as labeling recommends for pH-sensitive drugs. No further action is usually needed.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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