Drug interactions
Clopidogrel + Tucatinib
Severity: Moderate
Clopidogrel and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel's acyl-glucuronide metabolite inhibits CYP2C8, which contributes to tucatinib metabolism, so tucatinib levels may rise. This may increase adverse effects such as diarrhea and hepatotoxicity.
What this interaction means in plain words
Clopidogrel and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
CYP2C8 inhibition by clopidogrel glucuronide reduces tucatinib clearance.
What to do
Monitor liver enzymes and gastrointestinal tolerability; reduce tucatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Clopidogrel with Tucatinib?
MediHelp rates the interaction as moderate. Clopidogrel and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel's acyl-glucuronide metabolite inhibits CYP2C8, which contributes to tucatinib metabolism, so tucatinib levels may rise. This may increase adverse effects such as diarrhea and hepatotoxicity.
How serious is the interaction between Clopidogrel and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability; reduce tucatinib dose if toxicity develops.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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