Drug interactions
Clorazepate + Crofelemer
Severity: Minor
Clorazepate and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. A clinically meaningful increase in clorazepate exposure is not expected.
What this interaction means in plain words
Clorazepate and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Theoretical intestinal CYP3A4 inhibition by crofelemer with minimal systemic absorption.
What to do
No dose adjustment is needed. Monitor for unusual sedation only if other CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Clorazepate with Crofelemer?
MediHelp rates the interaction as minor. Clorazepate and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. A clinically meaningful increase in clorazepate exposure is not expected.
How serious is the interaction between Clorazepate and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for unusual sedation only if other CYP3A4 inhibitors are also used.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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